While overdose deaths from prescription opioids have nearly quadrupled since 1999, some of the most dangerous drugs don’t require a prescription.

Using data from the Food and Drug Administration for 2004 through 2015, HealthGrove looked at the 150 drugs that are involved in the highest number of adverse reactions and ranked them by the percent of these reactions classified as serious. For many of these reactions, the FDA database uses medical terminology, such as pyrexia and dyspnoea for fever and labored breathing, respectively.

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